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Earth Rated Pet Wipes for Dogs and Cats, Hypoallergenic, Cleaning and Hydrating, for Grooming Paws, Body and Butt, Unscented, 100 Count by Earth Rated
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Douxo S3 Pyo Shampoo, Contains 3% Chlorhexidine & 0.5% Ophytrium, Antiseptic & Hydrating, For Bacterial or Yeast Skin Infections, For Dogs and Cats, 6.7 fl. oz. (200mL) by Douxo
Editor’s Choice — discover the Douxo S3 Pyo Shampoo, Contains 3% Chlorhexidine & 0.5% Ophytrium, Antiseptic & Hydrating, For Bacterial or Yeast Skin Infections, For Dogs and Cats, 6.7 fl. oz. (200mL) by Douxo, built for performance and designed for life in the United States.
About Douxo S3 Pyo Shampoo, Contains 3% Chlorhexidine & 0.5% Ophytrium, Antiseptic & Hydrating, For Bacterial or Yeast Skin Infections, For Dogs and Cats, 6.7 fl. oz. (200mL)
- #1 non-prescription topical brand used and recommended by U.S. veterinarians for dogs and cats with infections/inflammatory dermatological disease
- Proven to disinfect, hydrate and help support the skin’s ecosystem and reduce yeast counts in 7 days
- Contains ophytrium, a purified natural ingredient that helps support the skin’s physical barrier for supple hydrated skin and helps soothe irritated skin
- Free from soaps, sulfates, parabens, dyes and nanoparticles
- For best results use with the DOUXO PYO Mousse
The Douxo S3 Pyo Shampoo, Contains 3% Chlorhexidine & 0.5% Ophytrium, Antiseptic & Hydrating, For Bacterial or Yeast Skin Infections, For Dogs and Cats, 6.7 fl. oz. (200mL) by Douxo combines reliability, modern design, and user-focused engineering. Perfect for everyday use, it delivers dependable results for American customers who value innovation.
Specification: Douxo S3 Pyo Shampoo, Contains 3% Chlorhexidine & 0.5% Ophytrium, Antiseptic & Hydrating, For Bacterial or Yeast Skin Infections, For Dogs and Cats, 6.7 fl. oz. (200mL) by Douxo
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Photos: Douxo S3 Pyo Shampoo, Contains 3% Chlorhexidine & 0.5% Ophytrium, Antiseptic & Hydrating, For Bacterial or Yeast Skin Infections, For Dogs and Cats, 6.7 fl. oz. (200mL) by Douxo
6196 reviews for Douxo S3 Pyo Shampoo, Contains 3% Chlorhexidine & 0.5% Ophytrium, Antiseptic & Hydrating, For Bacterial or Yeast Skin Infections, For Dogs and Cats, 6.7 fl. oz. (200mL) by Douxo
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Last updated on October 19, 2025 4:59 am Details
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Douxo S3 Pyo Shampoo, Contains 3% Chlorhexidine & 0.5% Ophytrium, Antiseptic & Hydrating, For Bacterial or Yeast Skin Infections, For Dogs and Cats, 6.7 fl. oz. (200mL) by Douxo
Original price was: $24.99.$21.99Current price is: $21.99.
Heather Graham –
My frenchie has severe allergies. After a food change, and bathes once a week with this shampoo, he feels so much better. I’ve even been able to stop his Cytopoint injections. The shampoo is very mild to be a chlorhexidine shampoo. I thought it might dry him out, especially using it once a week, but it hasn’t. It works very well, and smells nice too.
Heather –
Hands down the best dog shampoo I’ve ever used.y American Pitbull is allergic to everything,I even had him undergo the prick test with the Dermatologist & he’s allergic to 40 out of 46 items tested for. So his skin is always broken out, even while doing the Allergy Immunotherapy injections, I’m averaging every 3rd day on giving him another bath & this shampoo is helping him so much! He will be completely broken out, red bumps & hives all over his body, I’ll give him a bath & within a few hours, or by the next morning (since I usually bathe right before bed) his skin has significantly improved, half the bumps will be gone, most of the hives are completely gone & the redness is nonexistent!
The smell is really great as well, it’s a lighter scent, I don’t smell any chemicals or any of the normal medicated smell at all & it’s light enough you can smell it on your pup if you’re up close, but otherwise it’s not noticeable. The formula is decently thick, it’s not runny at all, but it suds up so great as well – another huge thing most medicated shampoos don’t do! You also only need a small amount, it actually advises how much to use on the bottle depending on how large your dog is, but it’s so easy to suds up, that you don’t need much at all. I have a 64lbs Pitbull & I only use 2 pumps on his whole back, 1 on each side & 1 pump on each leg & that’s about it. So the cost is a bit expensive, but it lasts forever with how little you need & with how well it works, its 100% worth it. The pump works great, it has the locking mechanism when you turn the pump to the side, so you don’t have to worry about it leaking, we transport it every weekend to our MIL’s house, and I just throw it in the bag, never leaked before, you don’t have to worry about it.
I can’t recommend this shampoo enough or stress how well its been working for our 4 dogs!
Tia&bobsmom –
Exactly as described. Beautiful scent and a little amount goes a long way. Love it.
Heather Graham –
With a pitty with severe allergies (white) her breakouts can get out of control. I have found that bathing her with this shampoo only once a week has done wonders – of course, in addition to her Prednisone every other day….
I recommend this shampoo for help with breakouts, itching, and redness. (I also use Rosemary oil for her paws/scarred areas after her bath)
Please note that I have been living with a white Pitty whos vet, food, and special items adds up to about $1,000.00 extra a year (in addition to regular doggie costs) but I will also say – not ALL dogs will react to a product the same way another one does. It will Always be trial and error with allergies and pets. Just like adults – ya gotta find what works for them 🙂
Good luck!
Tammy Klomps –
This is the best for skin condition that my pup had last December, he itched 24/7 and I felt so bad for him. His fur started falling out and his skin was red and bleeding,even had scabs on the bottoms of his ears. So his groomer used this on him and he started getting better from that moment on. I would give him a bath every third day for two weeks and left the shampoo in for 10 minutes and rinsed really good, he just kept getting better and better. After two weeks he was just like new and skin was cleared up and no more itching. So I would definitely recommend this product for a skin condition like my dog had helped him so much and put my mind at ease.
RaMona Schmitz –
les deja el pelaje suavecito y limpio
Sharon M –
This shampoo has been an absolute game-changer for my dog. She’s 13 years old now and has struggled with itching her entire life. We’ve tried just about everything over the years—multiple prescriptions, countless vet-recommended products, and so many over-the-counter solutions. Nothing ever gave her real relief until we started using this shampoo along with the mousse.
The difference has been incredible. She used to spend her days constantly scratching and licking, and nights were often the worst—waking up itching, sometimes even crying out in discomfort. It was heartbreaking to watch. Since switching to this product she’s finally comfortable. She sleeps peacefully through the night now, complete with the sweetest little snores, and during the day she’s relaxed instead of restless. It’s been amazing to see her quality of life improve so dramatically.
I’ve been using this consistently for months and I’m a repeat purchaser—I’ll never be without it. It not only calms her skin but also keeps her coat soft, clean, and so fresh smelling. I did find that buying directly from the company offers a better price, but regardless, this shampoo (and mousse) are worth every penny.
If you have a dog struggling with chronic itching or irritated skin, I can’t recommend this product enough. It has truly been the only thing that has worked for us after years of searching, and it’s given my dog the comfort she deserves.
Marion –
RaMona Schmitz –
My German shepherd has environmental allergies. This shampoo keeps him symptom free. It keeps his coat healthy and shiny. It is expensive but I pay the price to keep my boy comfortable. I love the way it makes his coat smell fresh and clean.
Andres Valencia –
This shampoo will make your pet fur so soft and shiny . And the best part is reduce her dander by 75% … she is more calm now .. less scratchy. Since we live in humid so I shower her every 4 – 5 days .